Description
erpin F1 (SERPINF1) is also known as Pigment epithelium-derived factor (PEDF), Cell proliferation-inducing gene 35 protein (PIG35).
Serpin F1 belongs to the serpin family.
Serpin F1 is expressed in quiescent cells.
PEDF has a variety of functions including antiangiogenic, antitumorigenic, and neurotrophic properties.
Endothelial cell migration is inhibited by SERPINF1/ PEDF.
PEDF / SERPINF1 suppresses retinal neovascularization and endothelial cell proliferation.
PEDF is also responsible for apoptosis of endothelial cells either through the p38 MAPK pathway or through the FAS/FASL pathway.
PEDF also displays neurotrophic functions